Mag^tm1Rod
Targeted Allele Detail

Summary

• Symbol: Mag^tm1Rod
• Name: myelin-associated glycoprotein; targeted mutation 1, John Roder
• MGI ID: MGI:1857216
• Gene: Mag Location: Chr7:30598601-30614298 bp, - strand Genetic Position: Chr7, 19.26 cM
• Alliance: Mag^tm1Rod page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18407
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 5 of the gene. Mutant mice showed a complete lack of mRNA and protein in the central nervous system for the targeted gene. Nerves from the peripheral nervous system also lacked protein for the targeted gene. (J:18407)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mag Mutation: 25 strains or lines available

References

• Original: J:18407 Li C, et al., Myelination in the absence of myelin-associated glycoprotein. Nature. 1994 Jun 30;369(6483):747-50
• All: 28 reference(s)