Mgat1^tm1Jxm
Targeted Allele Detail

Summary

• Symbol: Mgat1^tm1Jxm
• Name: mannoside acetylglucosaminyltransferase 1; targeted mutation 1, Jamey Marth
• MGI ID: MGI:1857217
• Gene: Mgat1 Location: Chr11:49135018-49153854 bp, + strand Genetic Position: Chr11, 29.27 cM
• Alliance: Mgat1^tm1Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68330
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the single protein coding exon. No protein activity was detectable in protein extracts derived from homozyogous mutant embryos. (J:68330)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mgat1 Mutation: 19 strains or lines available

References

• Original: J:68330 Metzler M, et al., Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development. EMBO J. 1994 May 1;13(9):2056-65
• All: 3 reference(s)