Mos^tm1Ev
Targeted Allele Detail

Summary

• Symbol: Mos^tm1Ev
• Name: Moloney sarcoma oncogene; targeted mutation 1, Martin L Evans
• MGI ID: MGI:1857218
• Synonyms: mos^-
• Gene: Mos Location: Chr4:3870658-3872105 bp, - strand Genetic Position: Chr4, 2.16 cM, cytoband A1-A2
• Alliance: Mos^tm1Ev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19118
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the middle of the single coding exon of the gene, introducing an amber stop codon into the reading frame and terminating translation upstream of sequences essential for kinase activity. (J:19118)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Mos Mutation: 21 strains or lines available

References

• Original: J:19118 Colledge WH, et al., Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs [see comments]. Nature. 1994 Jul 7;370(6484):65-8
• All: 12 reference(s)