Notch1^tm1Con
Targeted Allele Detail

Summary

• Symbol: Notch1^tm1Con
• Name: notch 1; targeted mutation 1, Ronald L Conlon
• MGI ID: MGI:1857230
• Synonyms: N1^delta1, Notch^-, Notch1^-, Notch1^tm1Con/J, Notch^delta1
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^tm1Con page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25248
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Deletion of sequences encoding the EGF repeats 28 to 36, three Notch repeats, the transmembrane domain and CDC10/SWI6 repeats, and replacement with a neomycin gene. (J:25248)

Expression

In Mice Carrying this Mutation:	111 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 117 strains or lines available

References

• Original: J:25248 Conlon RA, et al., Notch1 is required for the coordinate segmentation of somites. Development. 1995 May;121(5):1533-45
• All: 43 reference(s)