Nppa^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Nppa^tm1Unc
• Name: natriuretic peptide type A; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1857231
• Synonyms: ANP-, proANP-
• Gene: Nppa Location: Chr4:148085179-148086531 bp, + strand Genetic Position: Chr4, 78.66 cM
• Alliance: Nppa^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76312
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 11 bp of exon 2 was replaced with a neomycin resistance gene via homologous recombination. Radioimmunoassay of plasma and atria from homozygous mutant animals did not detect protein product. (J:76312)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nppa Mutation: 11 strains or lines available

References

• Original: J:76312 John SW, et al., Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science. 1995 Feb 3;267(5198):679-81
• All: 32 reference(s)