Ntf3^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Ntf3^tm1Jae
• Name: neurotrophin 3; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:1857232
• Synonyms: NT-3-, NT3^-
• Gene: Ntf3 Location: Chr6:126078375-126143703 bp, - strand Genetic Position: Chr6, 60.45 cM
• Alliance: Ntf3^tm1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23882
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The entire coding region for the Ntf3 gene was replaced by a neomycin cassette. (J:23882)

Expression

In Mice Carrying this Mutation:	92 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ntf3 Mutation: 24 strains or lines available

References

• Original: J:23882 Ernfors P, et al., Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell. 1994 May 20;77(4):503-12
• All: 47 reference(s)