Abcb4^tm1Bor
Targeted Allele Detail

Summary

• Symbol: Abcb4^tm1Bor
• Name: ATP-binding cassette, sub-family B member 4; targeted mutation 1, Piet Borst
• MGI ID: MGI:1857236
• Synonyms: mdr2-, Mdr2ko, mdr2^neo1, Pgy2^tm1Bor
• Gene: Abcb4 Location: Chr5:8943717-9009231 bp, + strand Genetic Position: Chr5, 3.43 cM
• Alliance: Abcb4^tm1Bor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15531
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 1 and 2. The translation initiation site is in exon 2. RNase proteiction assays indicated that mutant truncated transcripts are produced from this allele that contain exons 3-6 or 4-6. (J:15531)

Disease models

Expression

In Mice Carrying this Mutation:	8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Abcb4^tm1Bor

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abcb4 Mutation: 68 strains or lines available

References

• Original: J:15531 Smit JJ, et al., Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell. 1993 Nov 5;75(3):451-62
• All: 138 reference(s)