Ptgs2^tm1Jed
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm1Jed
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, Joe E Dinchuk
• MGI ID: MGI:1857239
• Synonyms: Cox-2-, COX-2-, COX2-, Ptgs2-
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm1Jed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29974
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.8 kb genomic fragment containing exon 1 and the transcription and translation start sites was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from embryonic fibroblasts derived from homozygous embryos demonstrated that no detectable transcript was produced from this allele. (J:29974)

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptgs2^tm1Jed

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 73 strains or lines available

References

• Original: J:29974 Dinchuk JE, et al., Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. 1995 Nov 23;378(6555):406-9
• All: 94 reference(s)