Rab3a^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Rab3a^tm1Sud
• Name: RAB3A, member RAS oncogene family; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:1857240
• Synonyms: Rab3a-
• Gene: Rab3a Location: Chr8:71207328-71211323 bp, + strand Genetic Position: Chr8, 34.15 cM
• Alliance: Rab3a^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64297
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced the promoter and the first two exons of the gene. Western blots of brain extracts did not detect any encoded protein in homozygous mice. (J:64297)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rab3a Mutation: 15 strains or lines available

References

• Original: J:64297 Geppert M, et al., The role of Rab3A in neurotransmitter release. Nature. 1994 Jun 9;369(6480):493-7
• All: 33 reference(s)