Rag1^tm1Mom
Targeted Allele Detail

Summary

• Symbol: Rag1^tm1Mom
• Name: recombination activating 1; targeted mutation 1, Peter Mombaerts
• MGI ID: MGI:1857241
• Synonyms: Rag-, Rag1^-, RAG-1-, Rag-1KO, RAG1^null, Rag^1tm1Mom
• Gene: Rag1 Location: Chr2:101468627-101479846 bp, - strand Genetic Position: Chr2, 53.88 cM
• Alliance: Rag1^tm1Mom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:1934
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1356 bp genomic fragment of the Rag1 gene, encoding the nuclear localization signal and the zinc-finger motif, was replaced by a neomycin cassette. A mutant transcript expressed from this allele was detected by Northern blot in bone marrow derived cell lines from homozygous mice. (J:1934, J:96036)

Disease models

Expression

In Mice Carrying this Mutation:	44 assay results 12 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rag1^tm1Mom

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 49 strains available Cell Lines: 0 lines available
• Carrying any Rag1 Mutation: 123 strains or lines available

References

• Original: J:1934 Mombaerts P, et al., RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 1992 Mar 6;68(5):869-77
• All: 1977 reference(s)