Ccl3^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Ccl3^tm1Unc
• Name: C-C motif chemokine ligand 3; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1857243
• Synonyms: CCL3^-, MIP-1alpha -, Scya3 -, Scya3^tm1Coo
• Gene: Ccl3 Location: Chr11:83538670-83540181 bp, - strand Genetic Position: Chr11, 51.04 cM
• Alliance: Ccl3^tm1Unc page

Hexb^tm1Rlp/Hexb^tm1Rlp mice exhibit Sandhoff disease phenotypes that are improved in Hexb^tm1Rlp/Hexb^tm1Rlp Ccl3^tm1Unc/Ccl3^tm1Unc mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28704
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette was used to delete a region including 300 nucleotides of the 5' untranslated region, all of exon 1, and a portion of exon 2. An absence of transcript was observed via Northern blot analysis of total mRNA derived from bone marrow macrophages isolated from homozygous mutant animals. (J:28704)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccl3 Mutation: 17 strains or lines available

References

• Original: J:28704 Cook DN, et al., Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science. 1995 Sep 15;269(5230):1583-5
• All: 73 reference(s)