Stat4^tm1Gru
Targeted Allele Detail

Summary

• Symbol: Stat4^tm1Gru
• Name: signal transducer and activator of transcription 4; targeted mutation 1, Michael J Grusby
• MGI ID: MGI:1857248
• Synonyms: Stat4-
• Gene: Stat4 Location: Chr1:52026307-52146348 bp, + strand Genetic Position: Chr1, 26.67 cM
• Alliance: Stat4^tm1Gru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34059
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The exon encoding amino acids 263 through 314 was disrupted by the insertion of a neomycin selection cassette. The encoded protein was undetectable in the thymi and lymph nodes of homozygous mutant mice by immunoblot analysis. (J:34059)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Stat4 Mutation: 64 strains or lines available

References

• Original: J:34059 Kaplan MH, et al., Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 1996 Jul 11;382(6587):174-7
• All: 184 reference(s)