Stat5a^tm1Mam
Targeted Allele Detail

Summary

• Symbol: Stat5a^tm1Mam
• Name: signal transducer and activator of transcription 5A; targeted mutation 1, Lothar Hennighausen
• MGI ID: MGI:1857249
• Synonyms: Stat5a-
• Gene: Stat5a Location: Chr11:100750177-100775995 bp, + strand Genetic Position: Chr11, 63.77 cM
• Alliance: Stat5a^tm1Mam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64278
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The promoter sequence, an untranslated exon, and two coding exons were replaced by a neomycin selection cassette. Western blot analysis of extracts immunoprecipitated from mammary tissue of homozygous mutant mice showed an absence of encoded protein. (J:64278)

Expression

In Mice Carrying this Mutation:	416144 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Stat5a Mutation: 48 strains or lines available

References

• Original: J:64278 Liu X, et al., Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 1997 Jan 15;11(2):179-86
• All: 38 reference(s)