Syn1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Syn1^tm1Sud
• Name: synapsin I; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:1857250
• Gene: Syn1 Location: ChrX:20726750-20787157 bp, - strand Genetic Position: ChrX, 16.37 cM, cytoband A1-A4
• Alliance: Syn1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15701
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1 of the gene. Immunoblots of brains from mutant mice showed no detectable protein. Immunocytochemistry of brains from mutant mice showed no detectable protein staining. (J:15701)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syn1 Mutation: 22 strains or lines available

References

• Original: J:15701 Rosahl TW, et al., Short-term synaptic plasticity is altered in mice lacking synapsin I. Cell. 1993 Nov 19;75(4):661-70
• All: 13 reference(s)