Syn2^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Syn2^tm1Sud
• Name: synapsin II; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:1857251
• Synonyms: Syn II KO
• Gene: Syn2 Location: Chr6:115111863-115258967 bp, + strand Genetic Position: Chr6, 53.2 cM, cytoband F
• Alliance: Syn2^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:26920
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene was inserted to replace exons 9 and 10. A lack of protein expression in homozygous mutant mice was observed using immunoblot analysis. (J:26920)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syn2 Mutation: 24 strains or lines available

References

• Original: J:26920 Rosahl TW, et al., Essential functions of synapsins I and II in synaptic vesicle regulation [see comments]. Nature. 1995 Jun 8;375(6531):488-93
• All: 16 reference(s)