Tap1^tm1Arp
Targeted Allele Detail

Summary

• Symbol: Tap1^tm1Arp
• Name: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP); targeted mutation 1, Philip Ashton-Rickardt
• MGI ID: MGI:1857253
• Synonyms: Abcb2^tm1Arp, TAP^-, TAP-1-, TAP1-
• Gene: Tap1 Location: Chr17:34406530-34416199 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Tap1^tm1Arp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3524
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 7kb region of the wild-type locus (which made up 80% of the protein coding region) was replaced by a neomycin resistance cassette. (J:3524)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Tap1 Mutation: 51 strains or lines available

References

• Original: J:3524 Van Kaer L, et al., TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell. 1992 Dec 24;71(7):1205-14
• All: 177 reference(s)