Tcrb^tm1Mom
Targeted Allele Detail

Summary

• Symbol: Tcrb^tm1Mom
• Name: T cell receptor beta chain; targeted mutation 1, Peter Mombaerts
• MGI ID: MGI:1857256
• Synonyms: beta-, CBeta^-, TCRb^-, TCRbeta-, TCR-Cbeta-
• Gene: Tcrb Location: Chr6:40868230-41535305 bp, + strand Genetic Position: Chr6, cytoband A-C

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22591
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 15kb of sequence was replaced with a PGK-neo cassette. The deletion included one of the two D gene segments, ten of the twelve J gene segments, and both constant gene segments. (J:22591)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tcrb^tm1Mom/Tcrb^tm1Mom	B6;129P2-Tcrb^tm1Mom/J
hm2	Tcrb^tm1Mom/Tcrb^tm1Mom	involves: 129P2/OlaHsd * BALB/c
cn3	Gt(ROSA)26Sor^tm10(Lmp1)Rsky/Gt(ROSA)26Sor^+ Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
cn4	Gt(ROSA)26Sor^tm10(Lmp1)Rsky/Gt(ROSA)26Sor^+ Tcrb^tm1Mom/Tcrb^+ Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ
cn5	Gt(ROSA)26Sor^tm11(Lmp1)Rsky/Gt(ROSA)26Sor^+ Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
cn6	Gt(ROSA)26Sor^tm11(Lmp1)Rsky/Gt(ROSA)26Sor^+ Tcrb^tm1Mom/Tcrb^+ Tcrd^tm1Mom/Tcrd^tm1Mom Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
cx7  Disease Model	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom Igh-J^tm2(3H9-VDJ*)Mwg/Igh-J^+	B6.129P2-Tcrb^tm1Mom Igh-J^tm2(3H9-VDJ*)Mwg Tcrd^tm1Mom
cx8	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	B6.129P2-Tcrb^tm1Mom Tcrd^tm1Mom/J
cx9	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom Traf3ip2^tm1.1Lix/Traf3ip2^tm1.1Lix	B6.129-Tcrb^tm1Mom Traf3ip2^tm1.1Lix Tcrd^tm1Mom
cx10	Tcrb^tm1Mom/Tcrb^+ Tg(SOD1*G93A)1Gur/0	B6.Cg-Tcrb^tm1Mom Tg(SOD1*G93A)1Gur/J
cx11	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	FVB.129P2-Tcrb^tm1Mom Tcrd^tm1Mom
cx12	Tcra^tm1Mom/Tcra^tm1Mom Tcrb^tm1Mom/Tcrb^tm1Mom	involves: 129 * BALB/c * C57BL/6
cx13	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	involves: 129 * BALB/c * C57BL/6
cx14	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	involves: 129P2/OlaHsd
cx15	Pigr^tm1Ohw/Pigr^tm1Ohw Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J
cx16	Tcrb^tm1Mom/Tcrb^tm1Mom Tg(KRT5-rtTA)1Glk/0 Tg(tetO/CMV-Tslp)#Sfz/0	involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N
cx17	Tcrb^tm1Mom/Tcrb^tm1Mom Tcrd^tm1Mom/Tcrd^tm1Mom	involves: 129P2/OlaHsd * C57BL/6
cx18	Il2^tm1Hor/Il2^tm1Hor Tcrb^tm1Mom/Tcrb^tm1Mom	involves: 129P2/OlaHsd * C57BL/6
cx19	Tcrb^tm1Mom/Tcrb^tm1Mom Tg(H2-K-Cd86)27All/0	involves: 129P2/OlaHsd * C57BL/6 * CBA
cx20	Tcrb^tm1Mom/Tcrb^tm1Mom Tg(H2-K-Cd86)7All/0	involves: 129P2/OlaHsd * C57BL/6 * CBA

Phenotypes:

Affected Systems	hm1	hm2	cn3	cn4	cn5	cn6	cx7	cx8	cx9	cx10	cx11	cx12	cx13	cx14	cx15	cx16	cx17	cx18	cx19	cx20
show or hide all annotated terms
cardiovascular system									√
abnormal glomerular capillary morphology									√
cellular									√
increased mesangial cell number									√
digestive/alimentary system		√											√					N
digestive/alimentary phenotype																		N
colitis		√											√
endocrine/exocrine glands		√										√	√
thymus hypoplasia		√										√	√
growth/size/body			√	√	√	√				√
weight loss										√
enlarged liver			√		√
enlarged spleen			√	√	√	√
hematopoietic system		√	√	√	√	√	√	√	√	√		√	√	√	√	√	√		N	√
hematopoietic system phenotype																			N	N
thymus hypoplasia		√										√	√
enlarged spleen			√	√	√	√
arrested T cell differentiation		√										√	√
increased T cell number														√
decreased lymphocyte cell number														√	√
decreased B cell number																				√
decreased plasma cell number								√
decreased T cell number								√	√
decreased double-positive T cell number		√										√	√
decreased CD4-positive, alpha-beta T cell number		√
absent CD4-positive, alpha-beta T cells													√
decreased CD8-positive, alpha-beta T cell number		√
absent CD8-positive, alpha-beta T cells													√
abnormal B cell morphology																				√
abnormal B cell differentiation																				√
abnormal transitional stage B cell morphology								√	√
increased B cell number			√	√	√	√		√
increased immature B cell number								√	√
increased transitional stage T2 B cell number								√
increased transitional stage T3 B cell number								√
increased mature B cell number								√
increased follicular B cell number								√
increased marginal zone B cell number							√	√	√
spleen hypoplasia							√
decreased IgA level														√
increased IgA level															√
decreased IgE level								√								√
decreased IgG level								√	√								√
decreased IgG1 level								√
increased IgM level								√	√
abnormal microglial cell physiology										√
immune system		√	√	√	√	√	√	√	√	√	N	√	√	√	√	√	√	N		√
immune system phenotype									N		N			N	N		N	N
colitis		√											√
thymus hypoplasia		√										√	√
enlarged spleen			√	√	√	√
arrested T cell differentiation		√										√	√
increased T cell number														√
decreased lymphocyte cell number														√	√
decreased B cell number																				√
decreased plasma cell number								√
decreased T cell number								√	√
decreased double-positive T cell number		√										√	√
decreased CD4-positive, alpha-beta T cell number		√
absent CD4-positive, alpha-beta T cells													√
decreased CD8-positive, alpha-beta T cell number		√
absent CD8-positive, alpha-beta T cells													√
abnormal B cell morphology																				√
abnormal B cell differentiation																				√
abnormal transitional stage B cell morphology								√	√
increased B cell number			√	√	√	√		√
increased immature B cell number								√	√
increased transitional stage T2 B cell number								√
increased transitional stage T3 B cell number								√
increased mature B cell number								√
increased follicular B cell number								√
increased marginal zone B cell number							√	√	√
spleen hypoplasia							√
decreased IgA level														√
increased IgA level															√
decreased IgE level								√								√
decreased IgG level								√	√								√
decreased IgG1 level								√
increased IgM level								√	√
abnormal microglial cell physiology										√
decreased autoantibody level								√
increased autoantibody level									√
increased anti-chromatin antibody level									√
increased anti-double stranded DNA antibody level							√		√
increased anti-histone antibody level									√
skin inflammation																√
abnormal response to infection																	√
integument																√
skin inflammation																√
abnormal dermal layer morphology																√
thick epidermis																√
liver/biliary system			√		√
enlarged liver			√		√
mortality/aging			√	√	√	√				√
premature death			√	√	√	√				√
neoplasm			√		√
increased B cell derived lymphoma incidence			√		√
increased plasmacytoma incidence			√		√
nervous system										√
abnormal microglial cell physiology										√
motor neuron degeneration										√
renal/urinary system								√	√
abnormal glomerular capillary morphology									√
increased mesangial cell number									√
renal glomerular immunoglobulin deposits								√	√
respiratory system	√							√									√
abnormal respiratory system morphology																	√
abnormal respiratory system physiology	√							√									√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cx7
systemic lupus erythematosus IDs systemic lupus erythematosus       DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141 Close	√

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tcrb^tm1Mom

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 12 strains available Cell Lines: 0 lines available
• Carrying any Tcrb Mutation: 97 strains or lines available

References

• Original: J:22591 Mombaerts P, et al., Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3084-7
• All: 519 reference(s)