Tcrd^tm1Mom
Targeted Allele Detail

Summary

• Symbol: Tcrd^tm1Mom
• Name: T cell receptor delta chain; targeted mutation 1, Peter Mombaerts
• MGI ID: MGI:1857257
• Synonyms: C-delta-, delta^-, delta⁰, gammadelta TCR^-, TCRdelta-, TCRdelta KO
• Gene: Tcrd Location: Chr14:54183530-54396655 bp, + strand Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3865
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene cassette was used to disrupt the constant gene segment (designated C-delta). Flow cytometry showed that cells isolated from the lymphoid or epithelial organs of homozygous mice did not react with an anti-pan Tcrd mAb. Immunoprecipitation showed an absence of expression on the surface of thymocytes isolated from homozygous mutant embryos. (J:3865, J:91942)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 13 strains available Cell Lines: 0 lines available
• Carrying any Tcrd Mutation: 16 strains or lines available

References

• Original: J:3865 Itohara S, et al., T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell. 1993 Feb 12;72(3):337-48
• All: 580 reference(s)