Tgfb3^tm1Doe
Targeted Allele Detail

Summary

• Symbol: Tgfb3^tm1Doe
• Name: transforming growth factor, beta 3; targeted mutation 1, Thomas Doetschman
• MGI ID: MGI:1857259
• Synonyms: TGF-beta3 null
• Gene: Tgfb3 Location: Chr12:86103519-86125815 bp, - strand Genetic Position: Chr12, 40.09 cM
• Alliance: Tgfb3^tm1Doe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29901
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 6, which encodes the active domain of the protein. RT-PCR analysis of RNA derived from whole E11.5 or E15.5 embryos did not detect any transcript produced from this allele in homozygous mice. (J:29901)

Expression

In Mice Carrying this Mutation:	109 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tgfb3 Mutation: 35 strains or lines available

References

• Original: J:29901 Proetzel G, et al., Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet. 1995 Dec;11(4):409-14
• All: 42 reference(s)