Tlx1^tm1Sjk
Targeted Allele Detail

Summary

• Symbol: Tlx1^tm1Sjk
• Name: T cell leukemia, homeobox 1; targeted mutation 1, Stanley J Korsmeyer
• MGI ID: MGI:1857260
• Synonyms: Hox11^-, Tlx-, Tlx1^-
• Gene: Tlx1 Location: Chr19:45139119-45145382 bp, + strand Genetic Position: Chr19, 38.45 cM
• Alliance: Tlx1^tm1Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17695
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette into codon 53. Transcript was undetected by in situ hybridization of homozygous mutant mice. (J:17695)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tlx1 Mutation: 20 strains or lines available

References

• Original: J:17695 Roberts CW, et al., Hox11 controls the genesis of the spleen. Nature. 1994 Apr 21;368(6473):747-9
• All: 15 reference(s)