Trp53^tm1Tyj
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Tyj
• Name: transformation related protein 53; targeted mutation 1, Tyler Jacks
• MGI ID: MGI:1857263
• Synonyms: p53-, p53^-, p53^delta, p53KO, p53^null, Trp53-, Trp53^KO
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Tyj page

Persistent hyperplastic primary vitreous (PHPV) in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs mice is p53 independent

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17728
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene cassette replaced 40% of the coding sequences beginning with exon 2 (upstream of the translation start site) and extending into exon 6. (J:17728)

Disease models

Expression

In Mice Carrying this Mutation:	120 assay results 9 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 12 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

Notes

This mutant allele was produced by a targeted neo insertion into the Trp53 locus. Homozygotes show no visible phenotype but develop tumors at 3-6 months of age. Heterozygotes develop tumors at 10 months of age. These mice model some of the features of human Li-Fraumeni syndrome (OMIM 151623), a form of familial breast cancer with mutations in TRP53 (J:16022)(J:16023) A specific human mutation found in hepatocellular carcinomas caused by hepatitis B infection or by aflatoxin exposure has been created in a mouse model, resulting in a similar gene product (J:27363).

References

• Original: J:17728 Jacks T, et al., Tumor spectrum analysis in p53-mutant mice. Curr Biol. 1994 Jan 1;4(1):1-7
• All: 1190 reference(s)