Twist1^tm1Bhr
Targeted Allele Detail

Summary

• Symbol: Twist1^tm1Bhr
• Name: twist basic helix-loop-helix transcription factor 1; targeted mutation 1, Richard R Behringer
• MGI ID: MGI:1857265
• Synonyms: twist-1^-, twist1^del
• Gene: Twist1 Location: Chr12:34007670-34009828 bp, + strand Genetic Position: Chr12, 14.81 cM, cytoband B-C1
• Alliance: Twist1^tm1Bhr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24349
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin selection cassette replaced exon 1, which contains the entire coding region. (J:24349)

Disease models

Expression

In Mice Carrying this Mutation:	319 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Twist1 Mutation: 18 strains or lines available

References

• Original: J:24349 Chen ZF, et al., twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev. 1995 Mar 15;9(6):686-99
• All: 48 reference(s)