Uox^tm1Bay
Targeted Allele Detail

Summary

• Symbol: Uox^tm1Bay
• Name: urate oxidase; targeted mutation 1, Baylor College of Medicine
• MGI ID: MGI:1857266
• Gene: Uox Location: Chr3:146302904-146337238 bp, + strand Genetic Position: Chr3, 72.09 cM
• Alliance: Uox^tm1Bay page

Pathology of urate neophropathy in Uox^tm1Bay/Uox^tm1Bay mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16490
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a neomycin cassette into exon 3 disrupted the open reading frame at codon 107. Western blot analysis revealed an absence of encoded protein in liver extracts from homozygous mutant mice. Spectrographic analysis showing a lack of urate oxidase activity in liver extracts, confirmed functional ablation in homozygous mutant mice. (J:16490)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Uox Mutation: 34 strains or lines available

References

• Original: J:16490 Wu X, et al., Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):742-6
• All: 13 reference(s)