Vldlr^tm1Her
Targeted Allele Detail

Summary

• Symbol: Vldlr^tm1Her
• Name: very low density lipoprotein receptor; targeted mutation 1, Joachim Herz
• MGI ID: MGI:1857267
• Synonyms: VLDLR-
• Gene: Vldlr Location: Chr19:27193884-27231631 bp, + strand Genetic Position: Chr19, 21.77 cM
• Alliance: Vldlr^tm1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28591
• Parent Cell Line: JH1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette into exon 5 deleted a portion of the coding sequence and disrupted the reading frame. Immunoblot analysis of heart muscle membranes did not detect protein in homozygous mutant animals. (J:28591)

Disease models

Expression

In Mice Carrying this Mutation:	20 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vldlr Mutation: 69 strains or lines available

References

• Original: J:28591 Frykman PK, et al., Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8453-7
• All: 110 reference(s)