Wt1^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Wt1^tm1Jae
• Name: WT1 transcription factor; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:1857268
• Synonyms: wt1^-
• Gene: Wt1 Location: Chr2:104956874-105003959 bp, + strand Genetic Position: Chr2, 55.06 cM, cytoband E
• Alliance: Wt1^tm1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:14317
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 1 and 0.5kb of upstream sequence were replaced with a neomycin selection cassette. (J:14317)

Disease models

Expression

In Mice Carrying this Mutation:	275 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Wt1^tm1Jae

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Wt1 Mutation: 34 strains or lines available

References

• Original: J:14317 Kreidberg JA, et al., WT-1 is required for early kidney development. Cell. 1993 Aug 27;74(4):679-91
• All: 55 reference(s)