Yes1^tm1Sor
Targeted Allele Detail

Summary

• Symbol: Yes1^tm1Sor
• Name: YES proto-oncogene 1, Src family tyrosine kinase; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:1857269
• Synonyms: p62^YesKO, yes^-, yes neo
• Gene: Yes1 Location: Chr5:32768515-32844401 bp, + strand Genetic Position: Chr5, 17.33 cM
• Alliance: Yes1^tm1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20346
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The yes gene was disrupted by insertion of a neomycin cassette into exon 7, which encodes the beginning of the kinase domain. A partial protein product has been reported in some cell types (see J:54973). (J:20346)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Yes1 Mutation: 138 strains or lines available

References

• Original: J:20346 Stein PL, et al., Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev. 1994 Sep 1;8(17):1999-2007
• All: 16 reference(s)