Rela^tm1Bal
Targeted Allele Detail

Summary

• Symbol: Rela^tm1Bal
• Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1, David Baltimore
• MGI ID: MGI:1857270
• Synonyms: Nfkb^1tmBal, p65-, rela^-
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm1Bal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28390
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted using neomycin resistance cassette. The vector replaced sequences encoding most of exons 6, 8 and the entire exon 7. Protein was not detectable by Western analysis in embryonic fibroblast extracts from homozygous mutant animals. (J:28390)

Expression

In Mice Carrying this Mutation:	59 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 28 strains or lines available

References

• Original: J:28390 Beg AA, et al., Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature. 1995 Jul 13;376(6536):167-70
• All: 57 reference(s)