Rela^tm1Bal
Targeted Allele Detail

Summary

• Symbol: Rela^tm1Bal
• Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1, David Baltimore
• MGI ID: MGI:1857270
• Synonyms: Nfkb^1tmBal, p65-, rela^-
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm1Bal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28390
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted using neomycin resistance cassette. The vector replaced sequences encoding most of exons 6, 8 and the entire exon 7. Protein was not detectable by Western analysis in embryonic fibroblast extracts from homozygous mutant animals. (J:28390)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	Rela^tm1Bal/Rela^tm1Bal	B6.129S4-Rela^tm1Bal
hm2	Rela^tm1Bal/Rela^tm1Bal	B6;129S4-Rela^tm1Bal/J
hm3	Rela^tm1Bal/Rela^tm1Bal	involves: 129S4/SvJae
hm4	Rela^tm1Bal/Rela^tm1Bal	involves: 129S4/SvJae * C57BL/6J
cx5	Rel^tm1Grd/Rel^tm1Grd Rela^tm1Bal/Rela^tm1Bal	B6.129S-Rel^tm1Grd Rela^tm1Bal
cx6	Nfkb1^tm1Bal/Nfkb1^tm1Bal Rela^tm1Bal/Rela^tm1Bal Tnf^tm1Ljo/Tnf^tm1Ljo	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae
cx7	Rel^tm1Grd/Rel^tm1Grd Rela^tm1Bal/Rela^tm1Bal Tnf^tm1Ljo/Tnf^tm1Ljo	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJae
cx8	Nfkb1^tm1Bal/Nfkb1^tm1Bal Rela^tm1Bal/Rela^tm1Bal	involves: 129P2/OlaHsd * 129S4/SvJae
cx9	Nfkb1^tm1Bal/Nfkb1^tm1Bal Rela^tm1Bal/Rela^+	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
cx10	Rela^tm1Bal/Rela^tm1Bal Tnf^tm1Ljo/Tnf^tm1Ljo	involves: 129S1/Sv * 129S4/SvJae * C57BL/6
cx11	Bid^tm1Sjk/Bid^tm1Sjk Rela^tm1Bal/Rela^tm1Bal	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
cx12	Rela^tm1Bal/Rela^tm1Bal Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx	involves: 129S4/SvJae * C57BL/6
cx13	Rela^tm1Bal/Rela^tm1Bal Tg(SERPINA1-BCL2)1Pva/0	involves: 129S4/SvJae * C57BL/6 * DBA/2

Phenotypes:

Affected Systems	hm1	hm2	hm3	hm4	cx5	cx6	cx7	cx8	cx9	cx10	cx11	cx12	cx13
show or hide all annotated terms
cardiovascular system	√			√	√						√	√
internal hemorrhage	√			√	√
liver hemorrhage											√
heart inflammation												√
cellular	√		√	√	√		√	√			√		√
abnormal cell cycle							√
abnormal cell death			√
decreased fibroblast apoptosis											√
increased neuron apoptosis			√
increased hepatocyte apoptosis	√			√	√								√
abnormal dendritic cell differentiation								√
abnormal monocyte differentiation					√
decreased cell proliferation							√
digestive/alimentary system									√
diarrhea									√
abnormal colon morphology									√
large intestinal inflammation									√
cecum inflammation									√
peritoneal inflammation									√
embryo							√
decreased embryo size							√
endocrine/exocrine glands												√
abnormal thymus morphology												√
growth/size/body							√					√
decreased embryo size							√
decreased body size												√
hematopoietic system			√		√			√				√
hematopoietic system phenotype					N
abnormal dendritic cell differentiation								√
abnormal monocyte differentiation					√
abnormal thymus morphology												√
decreased common myeloid progenitor cell number					√
abnormal erythropoiesis					√
extramedullary hematopoiesis												√
hyperchromasia					√
increased granulocyte number					√
decreased dendritic cell number								√
decreased marginal zone B cell number			√
abnormal spleen germinal center morphology												√
decreased spleen white pulp amount												√
homeostasis/metabolism		N
homeostasis/metabolism phenotype		N
immune system			√		√			√	√			√
immune system phenotype			N
heart inflammation												√
abnormal dendritic cell differentiation								√
abnormal monocyte differentiation					√
large intestinal inflammation									√
cecum inflammation									√
peritoneal inflammation									√
abnormal thymus morphology												√
increased granulocyte number					√
decreased dendritic cell number								√
decreased marginal zone B cell number			√
abnormal spleen germinal center morphology												√
decreased spleen white pulp amount												√
liver inflammation												√
lung inflammation												√
increased susceptibility to bacterial infection									√
integument						√	√
abnormal hair follicle placode formation							√
underdeveloped hair follicles							√
decreased hair follicle number							√
abnormal epidermal layer morphology							√
abnormal epidermis stratum basale morphology							√
abnormal keratinocyte morphology							√
thin epidermis						√	√
liver/biliary system	√			√	√						√	√	√
liver hemorrhage											√
increased hepatocyte apoptosis	√			√	√								√
liver inflammation												√
abnormal liver morphology											√
focal hepatic necrosis												√
liver degeneration				√
mortality/aging	√			√	√	√	√				√	√
lethality throughout fetal growth and development, complete penetrance	√			√							√
neonatal lethality, complete penetrance						√	√
postnatal lethality, complete penetrance												√
embryonic lethality during organogenesis, complete penetrance					√
prenatal lethality, incomplete penetrance						√
nervous system			√							√
abnormal trigeminal nerve morphology			√
abnormal nervous system physiology										√
abnormal neuron physiology			√
increased neuron apoptosis			√
respiratory system												√
lung inflammation												√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	59 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 28 strains or lines available

References

• Original: J:28390 Beg AA, et al., Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature. 1995 Jul 13;376(6536):167-70
• All: 57 reference(s)