Col2a1^Dmm
Radiation induced Allele Detail

Summary

• Symbol: Col2a1^Dmm
• Name: collagen, type II, alpha 1; disproportionate micromelia
• MGI ID: MGI:1857275
• Gene: Col2a1 Location: Chr15:97873483-97902525 bp, - strand Genetic Position: Chr15, 53.97 cM
• Alliance: Col2a1^Dmm page

Mutation origin

• Strain of Origin: (C3H x 101)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intragenic deletion
• Mutation details: This mutation is three-nucleotide deletion in the region encoding the C- propeptide globular domain. The deletion leads to the substitution of one amino acid, Asn, in the mutant for two amino acids, Lys and Thr, in the wild-type. (J:37522)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col2a1 Mutation: 69 strains or lines available

References

• Original: J:6582 Brown KS, et al., Disproportionate micromelia (Dmm): an incomplete dominant mouse dwarfism with abnormal cartilage matrix. J Embryol Exp Morphol. 1981 Apr;62(1):165-82
• All: 8 reference(s)