Aprt^tm1Jat
Targeted Allele Detail

Summary

• Symbol: Aprt^tm1Jat
• Name: adenine phosphoribosyl transferase; targeted mutation 1, Jay A Tischfield
• MGI ID: MGI:1857278
• Synonyms: Arpt-
• Gene: Aprt Location: Chr8:123301376-123303646 bp, - strand Genetic Position: Chr8, 71.91 cM
• Alliance: Aprt^tm1Jat page

Kidney histopathology of a Aprt^tm1Jat/Aprt^tmiJat mouse

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33255
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 3. RT-PCR analysis did not detect any transcript produced from this allele in samples derived from liver or lung of homozygous mice. APRT protein activity was not detectable in eryothrocyte lysates or in liver extracts derived from homozygous mice. (J:33255)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Aprt Mutation: 18 strains or lines available

References

• Original: J:33255 Engle SJ, et al., Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5307-12
• All: 18 reference(s)