Camk2a^tm1Sva
Targeted Allele Detail

Summary

• Symbol: Camk2a^tm1Sva
• Name: calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1, Alcino Silva
• MGI ID: MGI:1857279
• Synonyms: alpha-CaMKII-, alphaCaMKII-, alphaCaMKII^null, Camk2a^tm1
• Gene: Camk2a Location: Chr18:61058704-61121224 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Camk2a^tm1Sva page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:1421
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 130 bp DNA segment encoding the inhibitory domain and five amino acids of the calmodulin-binding domain was replaced with a neomycin selection cassette. Northern blot analysis on brain RNA derived from homozygous mice confirmed that no detectable transcript is produced from this allele. Western blot analysis on forebrain samples from homozygous mice demonstrated that no detectable protein is expressed from this allele. (J:1421)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Camk2a Mutation: 135 strains or lines available

References

• Original: J:1421 Silva AJ, et al., Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice [see comments]. Science. 1992 Jul 10;257(5067):201-6
• All: 23 reference(s)