Ccnd1^tm1Wbg
Targeted Allele Detail

Summary

• Symbol: Ccnd1^tm1Wbg
• Name: cyclin D1; targeted mutation 1, Robert A Weinberg
• MGI ID: MGI:1857280
• Synonyms: Ccnd1^1-3-, Ccnd1^delta1-3, CD1^-, cyclin D1-
• Gene: Ccnd1 Location: Chr7:144483668-144493568 bp, - strand Genetic Position: Chr7, 88.92 cM
• Alliance: Ccnd1^tm1Wbg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28419
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing part of exon 1, exon 2 and exon 3 was replaced with a neomycin selection cassette. The deleted sequences encode the cyclin box domain thought to be required for protein activity. Western blot analysis on embryonic fibroblasts derived from homozygous mice confirmed that no stable protein was made from this allele. (J:28419)

Expression

In Mice Carrying this Mutation:	18 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ccnd1^tm1Wbg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ccnd1 Mutation: 22 strains or lines available

References

• Original: J:28419 Sicinski P, et al., Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell. 1995 Aug 25;82(4):621-30
• All: 64 reference(s)