Cdh1^tm1Kem
Targeted Allele Detail

Summary

• Symbol: Cdh1^tm1Kem
• Name: cadherin 1; targeted mutation 1, Rolf Kemler
• MGI ID: MGI:1857282
• Synonyms: E-cad-
• Gene: Cdh1 Location: Chr8:107329983-107396878 bp, + strand Genetic Position: Chr8, 53.18 cM, cytoband D
• Alliance: Cdh1^tm1Kem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19904
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene and neomycin resistance cassette was inserted into exon 1 just upstream of the initiation codon of the gene. (J:19904)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdh1^tm1Kem

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh1 Mutation: 173 strains or lines available

References

• Original: J:19904 Larue L, et al., E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8263-7
• All: 12 reference(s)