Cybb^tm1Din
Targeted Allele Detail

Summary

• Symbol: Cybb^tm1Din
• Name: cytochrome b-245, beta polypeptide; targeted mutation 1, Mary C Dinauer
• MGI ID: MGI:1857284
• Synonyms: Cybb KO, Cybb^tm1, Cybbtm1Din, gp91-, gp91^phox-, gp91^phox, gp91phox^-, Nox-2^-, Nox2^-, NOX2^-, PHOX^-, X-CGD
• Gene: Cybb Location: ChrX:9301493-9354005 bp, - strand Genetic Position: ChrX, 4.3 cM
• Alliance: Cybb^tm1Din page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22868
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene was inserted into exon 3. Western blot analysis on extracts of neutrophil-rich peritoneal exudate cells from hemizygous male mice confirmed that no detectable protein was expressed. (J:22868)

Disease models

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cybb Mutation: 45 strains or lines available

References

• Original: J:22868 Pollock JD, et al., Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet. 1995 Feb;9(2):202-9
• All: 552 reference(s)