Plat^tm1Mlg
Targeted Allele Detail

Summary

• Symbol: Plat^tm1Mlg
• Name: plasminogen activator, tissue; targeted mutation 1, Richard C Mulligan
• MGI ID: MGI:1857288
• Synonyms: Plat^tm1, t-PA^-, tPA^-
• Gene: Plat Location: Chr8:23247743-23272860 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Plat^tm1Mlg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17427
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted using neomycin resistance cassette. The vector replaced genomic sequences encoding most of the kringle-2 domain and part of the proteinase domain, including the catalytically essential histidine residue at position 326. Targeting was confirmed by the absence of gene specific mRNA and immunoreactivity. (J:17427)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Plat Mutation: 60 strains or lines available

References

• Original: J:17427 Carmeliet P, et al., Physiological consequences of loss of plasminogen activator gene function in mice. Nature. 1994 Mar 31;368(6470):419-24
• All: 154 reference(s)