Plau^tm1Mlg
Targeted Allele Detail

Summary

• Symbol: Plau^tm1Mlg
• Name: plasminogen activator, urokinase; targeted mutation 1, Richard C Mulligan
• MGI ID: MGI:1857289
• Synonyms: u-PA^-, uPA-, UPA-
• Gene: Plau Location: Chr14:20886728-20893453 bp, + strand Genetic Position: Chr14, 11.53 cM
• Alliance: Plau^tm1Mlg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17427
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted using neomycin resistance cassette. The vector replaced genomic sequences encompassing all but 23 amino acids of the coding sequence. Targeting was confirmed by the absence of gene specific mRNA and immunoreactivity. (J:17427)

Disease models

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Plau^tm1Mlg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Plau Mutation: 29 strains or lines available

References

• Original: J:17427 Carmeliet P, et al., Physiological consequences of loss of plasminogen activator gene function in mice. Nature. 1994 Mar 31;368(6470):419-24
• All: 133 reference(s)