Plaur^tm1Jld
Targeted Allele Detail

Summary

• Symbol: Plaur^tm1Jld
• Name: plasminogen activator, urokinase receptor; targeted mutation 1, Jay L Degen
• MGI ID: MGI:1857290
• Synonyms: Plaur^tm1, uPAR^-
• Gene: Plaur Location: Chr7:24161909-24175393 bp, + strand Genetic Position: Chr7, 10.92 cM, cytoband A3
• Alliance: Plaur^tm1Jld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:26874
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, encoding the second half of the amino-terminal uPA binding domain, was replaced by an HPRT minigene. (J:26874)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Plaur Mutation: 18 strains or lines available

References

• Original: J:26874 Bugge TH, et al., The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility. J Biol Chem. 1995 Jul 14;270(28):16886-94
• All: 45 reference(s)