Plg^tm1Jld
Targeted Allele Detail

Summary

• Symbol: Plg^tm1Jld
• Name: plasminogen; targeted mutation 1, Jay L Degen
• MGI ID: MGI:1857291
• Synonyms: Plg^-, Plg⁰
• Gene: Plg Location: Chr17:12597496-12638271 bp, + strand Genetic Position: Chr17, 8.5 cM
• Alliance: Plg^tm1Jld page

Gross appearance of aortic arches of Apoe^tm1Bres/Apoe^tm1Bres, Plg^tm1Jld/Plg^tm1Jld and Apoe^tm1Bres/Apoe^tm1Bres Plg^tm1Jld/Plg^tm1Jld mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39419
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-HPRT minigene replaces proximal promoter sequences and the first two exons of the gene. Northern analysis and enzymatic activity assays were used to demonstrate the lack of a transcript and functional protein, respectively, in homozygous mutant animals. (J:39419)

Expression

In Structures Affected by this Mutation:

23 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Plg^tm1Jld

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Plg Mutation: 5 strains or lines available

References

• Original: J:39419 Bugge TH, et al., Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev. 1995 Apr 1;9(7):794-807
• All: 76 reference(s)