Icam1^tm1Jcgr
Targeted Allele Detail

Summary

• Symbol: Icam1^tm1Jcgr
• Name: intercellular adhesion molecule 1; targeted mutation 1, Jose Carlos Gutierrez Ramos
• MGI ID: MGI:1857292
• Synonyms: ICAM-1-, ICAM-1-deficient, ICAM^tm1-jcgr
• Gene: Icam1 Location: Chr9:20927281-20940113 bp, + strand Genetic Position: Chr9, 7.69 cM
• Alliance: Icam1^tm1Jcgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18743
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 4 of the gene. While King, et. al. (J:25530) reported the potential for the production of functional proteins arising from alternative transcripts, corresponding signals were undetected by immunohistochemical analysis of homozygous mutant mice. (J:18743)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Icam1 Mutation: 25 strains or lines available

References

• Original: J:18743 Xu H, et al., Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med. 1994 Jul 1;180(1):95-109
• All: 91 reference(s)