Hbb-b1^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Hbb-b1^tm1Unc
• Name: hemoglobin, beta adult major chain; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1857295
• Synonyms: Hbb^th-3, Hbb^th3
• Gene: Hbb-b1 Location: unknown Genetic Position: Chr7, 54.85 cM
• Alliance: Hbb-b1^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30155
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Hbb-b1 and Hbb-b2 were deleted using a two-step "plug and socket" method which leaves an hprt gene integrated in the genome. (J:20916)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hbb-b1 Mutation: 7 strains or lines available

References

• Original: J:30155 Yang B, et al., A mouse model for beta 0-thalassemia. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11608-12
• All: 69 reference(s)