Hprt1^b-m1
Transgenic Allele Detail

Summary

• Symbol: Hprt1^b-m1
• Name: hypoxanthine phosphoribosyltransferase 1; hypoxanthine guanine phosphoribosyl transferase B, mutation 1
• MGI ID: MGI:1857297
• Synonyms: Hprt-b^m1
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^b-m1 page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:15485
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Transgene description

• Transgene Type: Transgenic (Null/knockout)
• Mutation: Insertion
• A retroviral sequence was inserted into intron 1 in ES cells carrying Hprt^b. (J:3354)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1279 strains or lines available

References

• Original: J:15485 Kuehn MR, et al., A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature. 1987 Mar 19-25;326(6110):295-8
• All: 7 reference(s)