Mpv17
Transgenic Allele Detail

Summary

• Symbol: Mpv17
• Name: MpV17 mitochondrial inner membrane protein; Mpv17 retroviral insertion, kidney disease mutant
• MGI ID: MGI:1857300
• Synonyms: MPV-
• Gene: Mpv17 Location: Chr5:31298007-31311595 bp, - strand Genetic Position: Chr5, 17.12 cM
• Alliance: Mpv17 page

Transgene origin

• Strain of Origin: CFW

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: The Mpv17 mutation was generated by infection of CFW preimplantation mouse embryos with a recombinant retrovirus, MPSVneo, which carries a neo gene and is a replication-defective derivative of the myeloproliferative sarcoma virus, a Moloney murine leukemia virus-related RNA virus. (J:10661)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

24 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mpv17 Mutation: 28 strains or lines available

References

• Original: J:10661 Weiher H, et al., Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome. Cell. 1990 Aug 10;62(3):425-34
• All: 21 reference(s)