Mt1^tm1Bri
Targeted Allele Detail

Summary

• Symbol: Mt1^tm1Bri
• Name: metallothionein 1; targeted mutation 1, Ralph L Brinster
• MGI ID: MGI:1857301
• Synonyms: Mt1^tm1Br, Mt1tm1Bri, Mt1^tm/Bri, MT-KO
• Gene: Mt1 Location: Chr8:94905710-94906955 bp, + strand Genetic Position: Chr8, 46.34 cM
• Alliance: Mt1^tm1Bri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16487
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Both the Mt1 and Mt2 genes were simultaneously disrupted using a vector that inserted in-frame stop codons into the exons of the two genes. Mutant alleles are transcribed but not translated. (J:16487)

Tumor Data

List all tumor models in MMHCdb carrying Mt1^tm1Bri

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mt1 Mutation: 49 strains or lines available

References

• Original: J:16487 Masters BA, et al., Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):584-8
• All: 106 reference(s)