Ga
Allele Detail

Summary

• Symbol: Ga
• Name: greying with age
• MGI ID: MGI:1857316
• Gene: Ga Location: unknown
• Alliance: Ga page

Mutation origin

• Strain of Origin: wild

Mutation description

• Allele Type: Not Applicable
• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ga Mutation: 0 strains or lines available

Notes

Mice that become gray with age were found among wild mice in South Australia in 1970. Initially, the condition was ascribed to a dominant mutation with variation depending in part on genetic background and in part on maternal influence. All offspring of presumed heterozygous females mated to C57BL males were gray by 10 months of age, whereas only 6/65 offspring of the reciprocal cross were gray by that age. Morse et al. since have described a graying with age traceable to a maternally transmitted leukemia virus that causes melanocyte dysfunction subsequent to infection at pre- or early postnatal stages. The virus is not endogenous and is transmitted principally in milk. It is likely that viral transmission is responsible for the condition ascribed to Ga.

References

• Original: J:5460 Kirby GC, Greying with age: a coat-color variant in wild Australian populations of mice. J Hered. 1974 Mar-Apr;65(2):126-8
• All: 3 reference(s)