Rb1^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Rb1^tm1Brd
• Name: RB transcriptional corepressor 1; targeted mutation 1, Allan Bradley
• MGI ID: MGI:1857339
• Synonyms: Rb-, Rb-1^delta20
• Gene: Rb1 Location: Chr14:73430298-73563446 bp, - strand Genetic Position: Chr14, 38.73 cM, cytoband D3
• Alliance: Rb1^tm1Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:2516
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Insertion of a neomycin cassette into exon 20. (J:2516)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	34 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rb1^tm1Brd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rb1 Mutation: 111 strains or lines available

References

• Original: J:2516 Lee EY, et al., Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis [see comments]. Nature. 1992 Sep 24;359(6393):288-94
• All: 19 reference(s)