Rb1^tm2Mlh
Targeted Allele Detail

Summary

• Symbol: Rb1^tm2Mlh
• Name: RB transcriptional corepressor 1; targeted mutation 2, Martin L Hooper
• MGI ID: MGI:1857341
• Synonyms: Rb^t19neo
• Gene: Rb1 Location: Chr14:73430298-73563446 bp, - strand Genetic Position: Chr14, 38.73 cM, cytoband D3
• Alliance: Rb1^tm2Mlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:2498
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a PGK-neomycin resistance cassette into exon 19 disrupted the Rb1 gene. The authors predict that the Rb1 reading frame would be truncated upstream of the coding sequence for T-antigen binding domain number 2, and that therefore any gene product will be non functional. (J:2498)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rb1^tm2Mlh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rb1 Mutation: 111 strains or lines available

References

• Original: J:2498 Clarke AR, et al., Requirement for a functional Rb-1 gene in murine development [see comments]. Nature. 1992 Sep 24;359(6393):328-30
• All: 2 reference(s)