Reln^rl-Alb2
Chemically induced Allele Detail

Summary

• Symbol: Reln^rl-Alb2
• Name: reelin; reeler Albany recessive 2
• MGI ID: MGI:1857345
• Gene: Reln Location: Chr5:22089452-22549700 bp, - strand Genetic Position: Chr5, 9.98 cM, cytoband A3-B1
• Alliance: Reln^rl-Alb2 page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Transposon insertion
• Mutation details: Sequence analysis showed that this allele is the result of the insertion of a ~ 5 kb intracisternal A particle (IAP) between nucleotide 5815 to 5899 of an 85 nucleotide exon. This results in a premature stop codon and Northern analysis showed that this exon is not transcribed to mRNA in homozygous mutants. (J:41458)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Reln Mutation: 209 strains or lines available

References

• Original: J:41458 Royaux I, et al., Reln(rl-Alb2), an allele of reeler isolated from a chlorambucil screen, is due to an IAP insertion with exon skipping. Genomics. 1997 Jun 15;42(3):479-82
• All: 3 reference(s)