Grid2^ho-Tg37Inra
Transgenic Allele Detail

Summary

• Symbol: Grid2^ho-Tg37Inra
• Name: glutamate receptor, ionotropic, delta 2; hotfoot transgenic, nonhomologous insert 37, Institute National de la Rechevche
• MGI ID: MGI:1857384
• Synonyms: ho^TgN37INRA
• Gene: Grid2 Location: Chr6:63232860-64681307 bp, + strand Genetic Position: Chr6, 29.77 cM
• Alliance: Grid2^ho-Tg37Inra page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F2

Transgene description

• Transgene Type: Transgenic
• Mutation: Intragenic deletion
• Mutation details: Analysis of the transgene revealed that two complete and two truncated copies are inserted at the ho locus with an accompanying deletion of coding sequences. The resulting transcript contains a 4 kb deletion. (J:48151)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grid2 Mutation: 85 strains or lines available

Notes

Grid2^ho-TgN37Inra, hotfoot transgenic, nonhomologous insert 37, Institut National de la Recherche Agronomique. As the result of insertion of a trangene into the hotfoot locus, a new allele was formed that causes a phenotype resembling hotfoot in homozygotes and in heterozygotes with the Grid2^ho-4J allele (J:44452). A deletion in Grid2 mRNA in homozygotes for the new allele helps establish Grid2 as the site of the hotfoot mutations (J:48151).

References

• Original: J:44452 Lalouette A, et al., Construction of a high-resolution genetic map encompassing the hotfoot locus. Mamm Genome. 1997 Dec;8(12):903-6
• All: 2 reference(s)