Dsg3^tm1Stan
Targeted Allele Detail

Summary

• Symbol: Dsg3^tm1Stan
• Name: desmoglein 3; targeted mutation 1, John R Stanley
• MGI ID: MGI:1857388
• Synonyms: Dsg3^-
• Gene: Dsg3 Location: Chr18:20643331-20674367 bp, + strand Genetic Position: Chr18, 11.39 cM
• Alliance: Dsg3^tm1Stan page

Dsg3^tm1Stan/Dsg3^tm1Stan mice are runts and have skin erosions and eye lesions

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40804
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of part of the first exon, including the translation initiation site, with a neomycin cassette. Dsg3 RNA and protein were not detected in mice homozygous for this targeted mutation. (J:40804)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dsg3 Mutation: 74 strains or lines available

References

• Original: J:40804 Koch PJ, et al., Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol. 1997 Jun 2;137(5):1091-102
• All: 27 reference(s)