Bcl2l2^{Gt(ROSA)41Sor}
Gene trapped Allele Detail

Summary

• Symbol: Bcl2l2^{Gt(ROSA)41Sor}
• Name: BCL2-like 2; gene trap ROSA 41, Philippe Soriano
• MGI ID: MGI:1857389
• Synonyms: Bcl2l2^Gtrosa41, Bcl-w^-, Bclw^Gtrosa41
• Gene: Bcl2l2 Location: Chr14:55120900-55125691 bp, + strand Genetic Position: Chr14, 27.98 cM
• Alliance: Bcl2l2^{Gt(ROSA)41Sor} page

Mutation origin

• Mutant Cell Line: ROSA41
• Germline Transmission: Earliest citation of germline transmission: J:46386
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: ROSABetagal
• Mutation details: A ROSA Beta-gal provirus inserted into intron 2, 134 bp upstream of exon 3. RT-PCR analysis demonstrated that the transcript was absent in brain, salivary gland and testis of homozygous mice. Western blot analysis demonstrated an absence of the protein in brain and testes of homozygous mice. (J:46386)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  FHCRC-GT-ROSA41	CG465911 ; (MGI Seq Detail)	5' RACE	Chr14:55120851-55121340 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  1 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l2 Mutation: 19 strains or lines available

References

• Original: J:46386 Ross AJ, et al., Testicular degeneration in Bclw-deficient mice [see comments]. Nat Genet. 1998 Mar;18(3):251-6
• All: 14 reference(s)