Rasa1^tm1Paw
Targeted Allele Detail

Summary

• Symbol: Rasa1^tm1Paw
• Name: RAS p21 protein activator 1; targeted mutation 1, Tony Pawson
• MGI ID: MGI:1857417
• Gene: Rasa1 Location: Chr13:85362899-85437249 bp, - strand Genetic Position: Chr13, 45.05 cM
• Alliance: Rasa1^tm1Paw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29825
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette replaced a genomic fragment containing sequences encoding the N-terminal SH2 domain. Western blot analysis of total embryo protein lysates showed that no RASA1 protein was produced in homozygous mice. (J:29825)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rasa1 Mutation: 34 strains or lines available

References

• Original: J:29825 Henkemeyer M, et al., Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature. 1995 Oct 26;377(6551):695-701
• All: 2 reference(s)